Title | Organoid Models for Infectious Disease. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Blutt, SE, Estes, MK |
Journal | Annu Rev Med |
Volume | 73 |
Pagination | 167-182 |
Date Published | 2022 Jan 27 |
ISSN | 1545-326X |
Keywords | Communicable Diseases, Humans, Organoids |
Abstract | Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases. |
DOI | 10.1146/annurev-med-042320-023055 |
Alternate Journal | Annu Rev Med |
PubMed ID | 34644153 |
PubMed Central ID | PMC8887824 |
Grant List | U19 AI144297 / AI / NIAID NIH HHS / United States U24 DK085532 / DK / NIDDK NIH HHS / United States U19 AI116497 / AI / NIAID NIH HHS / United States U01 DK085532 / DK / NIDDK NIH HHS / United States P01 AI057788 / AI / NIAID NIH HHS / United States U01 DK103168 / DK / NIDDK NIH HHS / United States P30 DK056338 / DK / NIDDK NIH HHS / United States |