Organoid Models for Infectious Disease.

TitleOrganoid Models for Infectious Disease.
Publication TypeJournal Article
Year of Publication2022
AuthorsBlutt, SE, Estes, MK
JournalAnnu Rev Med
Date Published2022 Jan 27
KeywordsCommunicable Diseases, Humans, Organoids

Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases.

Alternate JournalAnnu Rev Med
PubMed ID34644153
PubMed Central IDPMC8887824
Grant ListU19 AI144297 / AI / NIAID NIH HHS / United States
U19 AI116497 / AI / NIAID NIH HHS / United States
P01 AI057788 / AI / NIAID NIH HHS / United States
U01 DK103168 / DK / NIDDK NIH HHS / United States
P30 DK056338 / DK / NIDDK NIH HHS / United States